Should research focus on searching for a cure or making existing treatments more effective? Introduction: General: Specific: what the different between treatment and cure/ some statistics about rising of diabetes world. Thesis: this essay will discuss effective present treatment for diabetes mellitus type 2 medications such as insulin and metformin and some lifestyle modifications such as exercise, nutrition and diabetes patient education. It will argue that studies should focus on future therapies to find a cure diabetes type 2 treatment such as genetic and bariatric surgery. Body paragraphs: Section A: diabetes type 2 medications. Bp1: Insulin therapy: Adv.: Initial glycaemic control treatment for diabetes type 2. (1,2) Temporary therapy to overcome glucose toxicity. (1,3) Metabolic improvement in short-term insulin therapy. (1) Re-regulate decompensated patients. (1) Sustained glycaemic improvement compare with other drugs. (4) Disadv: Causes hypoglycaemic. (2,3) Increase weight gain. (2,4) Severe liver and kidney dysfunction. (2) Need self-monitoring of blood glucose. (4) Bp 2 metformin: Adv:- Insulin resistance. (1) Decrease fasting hyperglycaemia. (1,2,3) Does not cause hypoglycaemia. (1,4) Does not cause weight increasing. (1,2,3) Reduce vascular mortality. (1) Increase insulin sensitivity. (2,3). Disadv: Cause lactic acidosis. (1,2,3,4) Gastrointestinal disturbance. (1,2,4) Long-term therapy causes deficiency in vitamin B12. (1) Severe liver & cardiac dysfunction. (2) Bp 3 evaluation : insulin therapy and metformin. Section B: lifestyle modifications as treatment: Bp 1: Exercise and diet (nutrition) and education : Adv:- Exercise Decrease blood glucose concentration. (1) Decrease basal and postprandial insulin conc. (1) Decrease A1c level. (1) Decrease lipids e.g. cholesterol and triglycerides. (1) Increase weight reduction. (5) Delaying the onset of diabetes. (5) Disadv: Exercise Causes hypoglycaemia. (1) Increase proteinuria. (1) Vitreous haemorrhage. (1) Soft tissue and joint injuries. (1) Adv: Nutrition Maintain optimal metabolic outcomes. (1) Keep glucose levels in normal range to reduce risk for diabetes. (1) Modify fat intake. (1) Improve food choices. (1) Disadv: can you find some Bp 2 :- Surgical Any surgical consider treatment. Bp 3 : Evaluation :Exercise and diet (nutrition)/Surgical Section C: future researches for cure type 2 diabetes: Bp 1: About genetic and bariatric surgery. Advantage and disadvantage. Bp 2: Any cure for diabetes type2. Adv / Disadv. Bp 3: Evaluation for Bp1 and Bp2. Bp4: Evaluation current treatment and cure depend on my position in thesis. Conclusion: Write the conclusion References: 1. ADA; Lebovitz (2009) 2. Cheng; Fantus (2005) 3. Olokoba et al. (2012) 4. Tahrani et al. (2011) 5. Kahan (2012) 6. Yamaoka; Tango (2005) Every body paragraph should have : 1. Topic sentence. 2. Main point. 3. Evidence/example/explanation . 4. Conclusion sentence. 5. Synthesis . The following references must be involved in this essay. However, I have only one book reference and I need at least two books references. So, you can add more reference that can help you. Thank you. BUT, GIVE ME PLEASE AN OUTLINE WITH THE ESSAY AS I MUST HAND IT IN TO MY TEACHER 1. American Diabetes Association; Lebovitz, Harold E. (2009). Therapy for Diabetes Mellitus and Related Disorders. Retrieved from http://www.eblib.com 2. Cheng, A. Y. Y., & Fantus, I. G. (2005). Oral antihyperglycemic therapy for type 2 diabetes mellitus. Canadian Medical Association.Journal, 172(2), 213-26. Retrieved from http://search.proquest.com/docview/204822496?accountid=10382 3. Olokoba, A. B., Obateru, O. A., & Olokoba, L. B. (2012). Type 2 diabetes mellitus: a review of current trends. Oman Med J, 27(4), 269-273. 4. Tahrani, A. A., Bailey, C. J., Del Prato, S., & Barnett, A. H. (2011). Management of type 2 diabetes: new and future developments in treatment. The Lancet, 378(9786), 182-197. 5. Kahn, R. (2012). Reducing the impact of diabetes: is prevention feasible today, or should we aim for better treatment?. Health Affairs, 31(1), 76-83. 6. Yamaoka, K., & Tango, T. (2005). Efficacy of lifestyle education to prevent type 2 diabetes: A meta-analysis of randomized controlled trials. Diabetes Care, 28(11), 2780-6. Retrieved from http://search.proquest.com/docview/223040539?accountid=10382
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